AETIOLOGY
Immediate Non Haemolytic Transfusion Reaction (IHTR)
INCIDENCE
Unusual
CLINICAL CULTURE
Fever, chills, facial flushing, pain in the chest, back, flank or abdomen, hypotension, nausea, vomiting, dysponea, haemoglobinuria, shock, oliguria or anuria, pain at transfusion site, generalized bleeding, urticaria, diarrhea, DIC, or: Intra-operative bleeding & or hypotension.
MANAGEMENT
Aim : Supportive treatment, watch for risk factors for DIC, hypotension & acute renal failure.
1. Stop transfusion.
2. Ethacrynic acid or furosemide, i/v.
3. For hypotension: i/v fluid and vasoactive drug (e.g. dopamine).
4. For bleeding diathesis or coagulation abnormalities give revevant blood components(FFP, Platelet concentrates, cryoprecipitaed Factor VIII).
PREVENTION
Ensure Proper patient identification, sample collection and labelling. Avoid mix-up between common names(e.g. John Smith, Amit Shah, Mani Iyer etc.)by giving identifying numbers in addition to the names.
Meticulous cross matching is a must. Do not insist on 'urgent' matching unless clinically indicated. Stick to group to group transfusions as far as possible.

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